The NFL is nothing if not unpredictable. Week 17, after all, delivered quite a few surprises, from the New York Giants stunning the Indianapolis Colts to the Kenny Pickett-led Philadelphia Eagles trouncing the Dallas Cowboys.

Ponnaiya's Prediction: Despite being one loss away from clinching the No. 1 overall pick in the upcoming draft, the Patriots are in a good position to beat their division rivals. The Buffalo Bills wrap up their regular season with a game against the New England Patriots on Sunday afternoon.

Titans (-1.5) all have a couple of things in common when deciding which contests to include in a Week 18 NFL parlay. They all involve one team that's locked into its current playoff seed, and all three of those teams are facing an opponent that has already been eliminated from postseason contention.

SportsLine's Model reveals its top Week 18 NFL picks, NFL best bets, NFL parlay picks, NFL parlay card, NFL predictions, and 25-1 football parlay

Doug Kezirian says the underdog Jaguars are the pick against the reeling Colts in Sunday’s NFL Week 18 action.

As the Philadelphia Eagles rest their starters for Week 18, bet on Jake Elliott taking the Over against the New York Giants.

One bettor turned $60 into almost $100k after wagering on every division winner in an eight-leg parlay. Patrick Everson has that scoop, plus other big bets from the weekend.