The EMBO Journal
WEB6 days ago · Unlocking metabolic insights with mouse genetic diversity. […] As part of EMBO Journal’s 2024 metabolism methods series, this commentary revisits the impact of genetics on metabolic studies, enabling dissection of novel mechanisms and phenotypes.
EMBO reports
WEBSep 10, 2024 · Nien-Pei Tsai. Neuronal hyperactivity and elevated susceptibility to seizures have been observed in early stage of Alzheimer’s disease. Accumulation of Aβ leads to an elevation of excitatory synapse numbers and seizure susceptibility, which can be ameliorated by inhibition of PSD-95. Science & Society12 January 2024.
Art and science: Intersections of art and science ... - EMBO reports
WEBDec 27, 2018 · Art and science have coexisted, often indistinguishable from each other, across time and space. A wealth of early documented examples comes from the Islamic culture, where art and science joined in intricate star‐shaped architectural geometries, and the use of “Nur” (light) and material science to design utensils and lettering in manuscripts 2.
The EMBO Journal
WEBPlease note that from 1 January 2024, The EMBO Journal is a fully Open Access (OA) journal. All articles are published with a CC-BY 4.0 license and all previously published content is freely available (please see OA FAQs here).The journal requires an Author Checklist and a Reagents and Tools Table to be submitted with ALL revised research articles.. For an illustrated technical guide to ...
The awesome lysosome - EMBO Molecular Medicine
WEBJan 19, 2016 · The lysosomal lumen has an acidic pH close to 4.5 and contains approximately 60 different soluble hydrolytic enzymes, which are directly involved in the degradation of metabolites.
Replicates and repeats—what is the difference and is it significant?:
WEBMar 16, 2012 · Let us suppose we are testing the hypothesis that the protein Biddelonin (BDL), encoded by the Bdl gene, is required for bone marrow colonies to grow in response to the cytokine HH‐CSF. Luckily, we have wild‐type (WT) and homozygous Bdl gene‐deleted mice at our disposal, and a vial of recombinant HH‐CSF. We prepare suspensions of bone marrow cells from a single WT and a single Bdl − ...
The EMBO Journal: Vol 43, No 18
WEBJul 22, 2024 · CMG helicase disassembly is essential and driven by two pathways in budding yeast. Cristian Polo Rivera. Tom D Deegan. Karim P M Labib. Pif1-family helicases mediate an ancestral pathway for replisome disassembly, which acts during S-phase to disassemble old CMG helicase complexes from the previous cell cycle.
Biodiversity crisis or sixth mass extinction?: - EMBO reports
WEBDec 9, 2021 · A couple of decades ago, some scientists suggested that the ongoing anthropogenic biodiversity crisis is similar in terms of scope to the five major mass extinctions that occurred in past geologic times and coined the term “sixth extinction” (Leakey & Levin, 1995).This term and its equivalent “sixth mass extinction” have become popular in both scientific and nonscientific debates and ...
Molecular mechanisms and physiological functions of mitophagy
WEBJan 13, 2021 · Figure 1. Overview of mitophagy. (1) Intra‐ and extracellular cues promote isolation of excess or damaged mitochondria via fragmentation of tubular networks. (2) Mitophagy receptors or ubiquitin–autophagy adaptors that confer selectivity for degradation are recruited and/or activated on the surface of mitochondria.
A guidebook for DISCO tissue clearing - Molecular Systems Biology
WEBMar 26, 2021 · These approaches have expanded the application of tissue clearing by providing specialized protocols for a variety of purposes. Figure 1. The most common tissue clearing methods. Tissue clearing methods can be separated into three main categories based on their chemistry: hydrogel‐based, hydrophilic, and hydrophobic.